ArticleClinical ophthalmology (Auckland, N.Z.)2025
Clinical Outcomes of Selective Laser Trabeculoplasty in Thai Glaucoma Patients Across Initial, Adjunctive, and Replacement Therapy.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate the outcomes of selective laser trabeculoplasty (SLT) in Thai glaucoma patients across three treatment groups-initial, adjunctive, and replacement therapy-and to identify predictors of treatment response and durability. Methods: This retrospective study included glaucoma patients who underwent SLT and were classified into initial, adjunctive, and replacement therapy groups. Treatment durability was analyzed using Kaplan-Meier survival methods. Predictors of non-response and shortened effects were identified using multivariable logistic regression and Cox proportional hazards models. Results: A total of 254 eyes from 123 patients were included: 76 eyes in the initial group, 117 in adjunctive therapy, and 61 in replacement therapy. Overall, 61.1% of eyes achieved a laser response, with significant variation among groups (initial 78.9%, replacement 68.9%, adjunctive 45.3%; Conclusion: SLT is effective and repeatable in Thai patients, particularly as initial or replacement therapy. While adjunctive therapy provides some benefit, patients with higher baseline IOP, heavier medication burden are more likely to experience non-response or shortened efficacy. Individualized selection and timely retreatment may optimize outcomes.
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