ArticleInternational journal of analytical chemistry2025
A Comparative Study in Metformin Tablet Quality Assessment: LC-MS and LC-MS/MS Method Quantification of N-Nitroso-Dimethylamine in the Presence of Dimethyl Formamide.
Article in International journal of analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Innovative Biosensor Platforms for the Detection of Metformin in Diabetes Management.International journal of analytical chemistry · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
N-nitroso-dimethylamine (NDMA, acceptable daily intake limit 96 ng/day), a probable human carcinogenic impurity, has been reported in metformin formulations. In some cases, it is difficult to accurately detect its presence due to suboptimal extraction technique(s), coelution of other probable human carcinogenic impurities such as dimethyl formamide (DMF) and/or ionization suppression in mass spectroscopic measurements. In this study, we provided a simple method to address DMF artifact using an affordable high-performance liquid chromatography coupled with a single-stage mass spectrometer. The results were further confirmed by dual-stage mass spectrometry. The two developed methods can simultaneously identify NDMA in the presence of DMF with good linear range from 10 to 100 ng/mL (
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