Evidence map›Paper›PMID 41368102›Full record

ArticleBiomedical optics express2025

Label-free visualization and quantitative analysis of Far UV-C skin safety with dynamic optical coherence tomography with subcellular resolution.

Felix Hilge, Michael Wang-Evers, Lara Buhl, Heather Downs, Maron Dolling, Lukas Pohl, Reginald Birngruber, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, Dieter Manstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Felix HilgeCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.ORCID https://orcid.org/0009-0009-1422-9221
Michael Wang-EversCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.ORCID https://orcid.org/0000-0002-6461-4891
Lara BuhlWellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA.
Heather DownsCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Maron DollingInstitute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Lukas PohlCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.
Reginald BirngruberInstitute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Hinnerk Schulz-HildebrandtWellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA.ORCID https://orcid.org/0000-0003-4389-9151
Gereon HüttmannInstitute of Biomedical Optics, University of Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0002-5051-3037
Dieter MansteinCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Boston, MA 02129, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent COVID-19 pandemic sparked interest in interventional public health measures like ultraviolet germicidal irradiation (UVGI) of occupied spaces with the development of Far UV-C (200-230 nm) emitting sources promising similar antimicrobial properties as conventional (254 nm) disinfecting lamps without adverse effects on human skin. When investigating the impact of different UV irradiation parameters, the visualization of cellular damage, like apoptosis and formation of photoproducts, currently requires immunohistochemical tissue processing and is of an invasive nature. Dynamic-microscopic optical coherence tomography (dmOCT) is a non-invasive technique that generates label-free images based on the dynamic scattering properties of cells. In this study, we expose an in-vitro human skin model to either UV-A/B or Far UV-C to demonstrate the ability of dmOCT to visualize cell death, followed by UV-induced photodamage, and perform immunohistochemical analysis. Our results clearly show a change in dynamic contrast within the viable epidermis and changes in the morphology of keratinocyte nuclei after UV-A/B exposure with 250 mJ/cm

Identifiers

PMID41368102
PMCPMC12684071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.