Evidence map›Paper›PMID 41368082›Full record

ArticleBiomedical optics express2025

High-speed wide-field fluorescence lifetime imaging for intraoperative tumor visualization and in vivo multiplexing.

Murali Krishnamoorthy, Rahul Pal, Steven S Hou, Hak Soo Choi, Brian J Bacskai, Alexei A Bogdanov, Kenneth K Tanabe, Mark A Varvares, Anand T N Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Real-Time SLAM-Based Correction and 3D Visualization for Fluorescence Lifetime Imaging.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Murali KrishnamoorthyDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4834-4991
Rahul PalDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Hospital, Harvard Medical School, Boston, MA, USA.
Steven S HouDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hak Soo ChoiHarvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7982-6483
Brian J BacskaiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alexei A BogdanovDepartment of Radiology, UMASS Chan Medical School, Worcester, MA, USA.
Kenneth K TanabeDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mark A VarvaresDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Hospital, Harvard Medical School, Boston, MA, USA.
Anand T N KumarDepartment of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Hospital, Harvard Medical School, Boston, MA, USA.

Funding

Fluorescence lifetime-based tumor contrast enhancement using exogenous probesR01DE033427 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI Anand T.N. Kumar · 2023 to 2026
$1.9M
Fluorescence lifetime-based intraoperative imaging system for sarcoma surgeriesR01EB036978 · NIBIB · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Anand T.N. Kumar · 2025 to 2026
$1.2M
NIBIB NIH HHS R01 EB036978NIDCR NIH HHS R01 DE033427
6 · The paper itself

Abstract

We present a technique for fast wide-field fluorescence lifetime (FLT) imaging using simultaneous steady-state and time- (or frequency-) domain measurements acquired in a single shot and exploiting the theoretical dependence of fluorescence intensity on FLT. Using theory, simulations, and

Identifiers

PMID41368082
PMCPMC12684027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.