ArticleCureus2025
Clinical Significance of Lactate Dehydrogenase A Expression in Colorectal Cancer.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- RPS2 and EEF1B2 are associated with glycolysis-related malignant phenotypes in COAD.American journal of cancer research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMetabolic reprogramming, characterized by alterations in metabolic pathways to support energy production and biosynthesis, is a hallmark of cancer and is exemplified by the Warburg effect. This process plays a pivotal role in tumor progression and is evident across multiple cancer types, including colorectal cancer (CRC).
objectivesThis study aimed to investigate the expression profiles of metabolism-related genes in CRC cells at early and advanced stages and to validate the expression of selected genes in CRC tissue samples.
methodsTissues from patients with early and advanced stages of CRC were collected to investigate the expression profiles of metabolism-related genes using microarray analysis. Selected genes were further validated at both the mRNA and protein levels by reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC), respectively. Based on gene profiling from microarray analysis, the metabolism-related gene lactate dehydrogenase A (LDHA) was selected for further investigation. A retrospective evaluation of LDHA expression was conducted using 260 formalin-fixed, paraffin-embedded (FFPE) tissue sections obtained from CRC patients diagnosed between January 2021 and December 2023 at the National Cancer Institute, Thailand.
resultsComparative analysis revealed 758 upregulated and 619 downregulated pathways in early-stage CRC and 630 upregulated and 614 downregulated pathways in advanced-stage CRC. From all of these pathways, altered metabolism-related pathways were predominantly associated with glycolysis, oxidative phosphorylation, and CRC metabolic reprogramming. Among metabolism-related genes, LDHA exhibited significantly elevated expression in CRC tissues compared to adjacent normal tissues, with marked increases at both mRNA and protein levels in early and advanced stages. Statistical analysis demonstrated a significant correlation between LDHA expression and metastasis to lymph nodes as well as distant organs, including the lungs and liver.
conclusionsThese findings suggest that metabolic reprogramming is strongly linked to CRC progression and that LDHA may serve as a promising biomarker for CRC screening, prognosis, and therapeutic intervention.
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Registered trials
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