Evidence map›Paper›PMID 41367965›Full record

ArticleJAACAP open2025

Substance Use, Suicidal Behavior, and Other Mental Health Outcomes Among Youth With Intersectional Sexual and Gender Diverse Identities.

Gladys N Pachas, Harrison T Reeder, A Eden Evins, Kelly Casottana, Marta Borrego Mahiques, Alec Bodolay, Caroline A Gray, Kevin W Potter, Alex S Keuroghlian, Randi M Schuster

Abstract read
In one paragraph

Article in JAACAP open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gladys N PachasMassachusetts General Hospital, Boston, Massachusetts.
Harrison T ReederMassachusetts General Hospital, Boston, Massachusetts.
A Eden EvinsMassachusetts General Hospital, Boston, Massachusetts.
Kelly CasottanaMassachusetts General Hospital, Boston, Massachusetts.
Marta Borrego MahiquesMassachusetts General Hospital, Boston, Massachusetts.
Alec BodolayMassachusetts General Hospital, Boston, Massachusetts.
Caroline A GrayMassachusetts General Hospital, Boston, Massachusetts.
Kevin W PotterMassachusetts General Hospital, Boston, Massachusetts.
Alex S KeuroghlianMassachusetts General Hospital, Boston, Massachusetts.
Randi M SchusterMassachusetts General Hospital, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Sexual diverse (SD) and gender diverse (GD) youth are at increased risk for adverse mental health outcomes compared to heterosexual/cisgender youth (HC). In this study, we aimed to examine youth risk profiles. We hypothesized that there would be a synergistic effect of SD+GD on mental health outcomes. Method: In 2022, a total of 23,915 adolescents in grades 6 to 12 from 60 schools completed the voluntary, confidential Substance Use and Risk Factor (SURF) survey. Questions included screeners for substance use and mental health distress. Regression models examined associations between mental health outcomes and HC, GD, SD, and SD+GD. Results: Mean age was 14.7 years; 25% identified as SD, 5.3% as GD, and 5.2% as SD+GD. Compared to HC, SD+GD youth had higher odds of depression (95% CI = 4.8-6.3), anxiety (95% CI = 4.9-6.5), suicidal thoughts (95% CI = 7.7-10.1), plans (95% CI = 6.7-8.8), attempts (95% CI = 7.0-10.7), nonsuicidal behavior (95% CI = 7.19-9.55), psychotic-like experiences (PEs) (95% CI = 4.1-5.4), emotional reactivity (ER) (95% CI = 22.1-24.5), alcohol use (95% CI = 1.2-2.4), cannabis use (95% CI = 2.3-4.0), smoking (95% CI = 9.4-26.6), and vaped nicotine (95% CI = 1.5-2.6) (all Conclusion: Although the GD only group is small, these findings on intersectional SD+GD identities have significant implications for adolescent mental health.

Indexed as

depressiondisparitiesLGBTQIA2S+mental healthsuicide

Identifiers

PMID41367965
PMCPMC12684452

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.