ArticleJAACAP open2025
A Relational Agent Intervention for Adolescents Seeking Mental Health Treatment: Outcomes From a Randomized Controlled Trial Within a Children's Outpatient Hospital.
Article in JAACAP open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05372913 (A Randomized Controlled Trial of the Feasibility and Acceptability of W-GenZD Versus CBT-light Teletherapy for Adolescents Seeking Mental Health Services), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of the Feasibility and Acceptability of W-GenZD Versus CBT-light Teletherapy for Adolescents Seeking Mental Health Services
Who cites it
1 citing paper in PubMed.
- Clinicians' provision of a self-guided digital mental health intervention to adolescents with depressive symptoms at preventive health visits in California.Preventive medicine reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Despite steady increases in the prevalence of depression and anxiety, many adolescents remain undertreated. Digital mental health interventions (DMHI) may address some barriers to care. This study is the first to examine the prospective noninferiority of a smartphone-based, self-guided relational agent (W-GenZD) DMHI to address adolescent depressive symptoms compared to group-based telehealth cognitive-behavioral therapy (CBT). Method: Adolescents 13 to 17 years of age who were seeking treatment for depression and/or anxiety at a children's hospital outpatient mental health program and who met study inclusion criteria were randomized to either W-GenZD (n = 71) or CBT Group (n = 70). The primary aim was to examine feasibility and acceptability. The secondary aim was to test the noninferiority of W-GenZD compared to CBT Group on the 8-item Patient Health Questionnaire (PHQ-8) at 4 weeks (end of treatment [EOT]). The study also examined the trajectory of working alliance, anxiety, general mood, and safety in each intervention group. Results: W-GenZD was noninferior to CBT Group in reducing depressive symptoms, with a mean between-group PHQ-8 EOT score difference of -0.67, 95% CI = - 2.30, 0.82 in intent-to-treat analysis (N = 141) using multiple imputation for missing values. Four different sensitivity analyses confirmed noninferiority, including per protocol analysis (-1.38, -3.61, 0.86, n = 82). Feasibility, acceptability, and tertiary aims were similar in both groups, and data support the safety of W-GenZD in a mental health outpatient setting. Conclusion: Results suggest that W-GenZD is a feasible and efficacious intervention for adolescents presenting with depression and/or anxiety in a real-world setting. W-GenZD could help expand the capacity of mental health clinicians to support the many youth and families in need of mental health care. Clinical trial registration information: Feasibility and Acceptability of W-GenZD vs CBT-light Teletherapy for Adolescents Seeking Mental Health Services; https://clinicaltrials.gov/study/NCT05372913.
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