ArticleFrontiers in endocrinology2025
Effect of vitamin D deficiency on clinical pregnancy outcomes in women with polycystic ovary syndrome undergoing
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to investigate the effect of serum vitamin D levels on Methods: This retrospective cohort study included patients with PCOS who underwent IVF therapy and received fresh embryo transfer for the first time. The enrolled cohort was divided into two groups based on serum 25-hydroxyvitamin D (25(OH)D) levels: Vitamin D deficiency (25(OH)D < 20 ng/mL) and vitamin D replete-insufficiency (25(OH)D ≥ 20 ng/mL). The primary outcome was clinical pregnancy. The secondary outcomes were the number of oocytes retrieved, MII oocytes, fertilized embryos, available embryos, high-quality embryos, blastocysts formed, and live birth rates. Results: This study included 613 patients who underwent their first IVF-ET cycle. Clinical pregnancy rates were significantly lower in patients with PCOS who had vitamin D deficiency than in those who had vitamin D replete-insufficiency [58.3% (211/367) versus 67.1% (163/246); Conclusion: This study suggests that vitamin D deficiency leads to lower clinical pregnancy rates in patients with PCOS undergoing IVF-ET. Furthermore, the serum vitamin D level is independently associated with clinical pregnancy rates in patients with PCOS undergoing IVF-ET.
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