ArticleBlood global hematology2025
Hydroxyurea Therapy in Sickle Cell Disease: Evaluating Healthcare Costs and Utilization in a Brazilian Tertiary Setting.
Article in Blood global hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Geographic and Temporal Differences in Sickle Cell Disease Hospitalizations in New York State.JAMA network open · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Patients with sickle cell disease (SCD) treated with hydroxyurea, a disease-modifying agent, experience reduced hospitalizations, blood utilization, opioid use, and mortality, but how the reduced acute care utilization translates to cost-savings is understudied. This study aimed to test whether hydroxyurea reduces overall care costs for SCD patients in Brazil. Healthcare costs in Brazilian Reais (R$) were collected from patients with SCD who had at least one encounter between January 1, 2018, and June 30, 2018. The total median healthcare resource utilization included ambulatory clinic, emergency department (ED), and inpatient care. Patients were stratified by hydroxyurea use and medication adherence (MPR >50% vs. ≤50%). A total of 3331 active patients were included in the analysis, with 3032 having at least one encounter. 51% were female, and the median age was 15 years (range 0-76). 2212 (73.0%), had HbSS/Sβ°thalassemia, followed by HbSC (n=610, 20%) and HbSβ
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