Evidence map›Paper›PMID 41367867›Full record

ArticleFrontiers in oncology2025

Mechanistic insights into GPAA1-mediated cold tumor phenotype and immune evasion in colorectal cancer: integrative multi-omics analysis and experimental validation.

Jia Zhu, Tao Zhu, Yichen Cai, Hancheng Fan

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jia ZhuDepartment of Pathology at Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Tao ZhuDepartment of Pathology at Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yichen CaiDepartment of Pathology at Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hancheng FanDepartment of Pathology at Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glycosylphosphatidylinositol(GPI) Anchor Attachment Protein 1 (GPAA1) plays a critical role in GPI-anchor biosynthesis, yet its pan-cancer expression patterns and functional significance in Colorectal Cancer(CRC) remain unclear. Methods: We integrated multi-omics data (TCGA, GTEx, GEO, HPA) to analyze GPAA1 expression, immune infiltration, and genomic instability in CRC. Single-cell/spatial transcriptomics and functional assays (proliferation, migration, invasion) were performed to validate findings. Results: GPAA1 was significantly overexpressed in CRC (mRNA and protein, Conclusion: GPAA1 drives CRC progression via genomic instability and immunosuppression, serving as a prognostic biomarker and potential therapeutic target.

Indexed as

cold tumorcolorectal cancerGPAA1immune evasiontumor microenvironment

Identifiers

PMID41367867
PMCPMC12682669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.