Evidence map›Paper›PMID 41367822›Full record

ArticleBiochip journal2025

Multiplex Magnetic Biosensor Microarrays Facilitate Personalized Vaccination Schedules for SARS-CoV-2 Variants.

Hyun-Kyung Um, Songeun Kim, Jueun Hwang, Yeeun Lee, Shan X Wang, Jung-Rok Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochip journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hyun-Kyung UmDepartment of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.
Songeun KimDepartment of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.
Jueun HwangDepartment of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.
Yeeun LeeDepartment of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.
Shan X WangDepartment of Materials Science and Engineering, Stanford University, Stanford, CA 94305, USA.
Jung-Rok LeeDepartment of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0002-3518-3965

Funding

Rapid and affordable magneto-nanosensors for ctDNA-guided lung cancer managementR01CA257843 · NCI · STANFORD UNIVERSITY · PI WANG, SHAN X. · 2021 to 2024
$2.2M
MagSToNE - a magnetic system for kidney stone fragment eliminationR21DK131776 · NIDDK · STANFORD UNIVERSITY · PI LIAO, JOSEPH C, WANG, SHAN X. · 2021 to 2022
$435k
NCI NIH HHS R01 CA257843NIDDK NIH HHS R21 DK131776
6 · The paper itself

Abstract

Rapid, sensitive, multiplexed antibody detection technologies are essential for assessing vaccine efficacy and recipient immunity against viruses. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge and novel viruses may pose potential threats in the near future, personalized vaccines can be precisely tailored to an individual's measured immunity to help mitigate the symptoms of infection and viral spread. Here, we present giant magnetoresistive (GMR) biosensor microarrays for the quantitative multiplexed detection of antibodies against SARS-CoV-2 variants. The multiplexed GMR biosensor microarrays demonstrated high sensitivity, comparable to that of the single-plex enzyme-linked immunosorbent assay, enabling multiplexed measurements using blood obtained from finger pricks. Additionally, the GMR biosensor microarrays demonstrated compatibility with clinical samples and could detect variant-specific antibodies in serum, allowing for the assessment of current immunity status. Notably, an increased concentration of antibodies against the Omicron variant was clearly observed two weeks after receiving an Omicron-based booster vaccination. These results indicate that GMR biosensor microarrays offer a practical point-of-care tool for monitoring humoral immunity and guiding personalized vaccination schedules, thereby supporting immunity management against SARS-CoV-2 and future viral threats.

Indexed as

Giant magnetoresistanceMagnetic biosensorsMagnetic nanoparticlesNeutralizing antibodiesVaccinationViral variants

Identifiers

PMID41367822
PMCPMC12685006

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.