ArticleQuantitative imaging in medicine and surgery2025
Cerebral microstructural alteration patterns in motor subtypes of Parkinson's disease: a neurite orientation dispersion and density imaging study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Superficial white matter (SWM) microstructural alterations in Parkinson's disease: a neurite orientation dispersion and density imaging and diffusion tensor imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Subcortical microstructural impairment in amyotrophic lateral sclerosis: clinical correlates of neurite orientation dispersion and density imaging (NODDI) changes.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tremor-dominant (TD) and postural instability and gait difficulty (PIGD) are motor subtypes of Parkinson's disease (PD) characterized by distinct clinical and disease progression. For these subtypes, the microstructural alterations in white matter (WM) and gray matter (GM), such as axonal density or dispersion, remain unclear. We aimed to ascertain distinct microstructural alterations in WM and GM between TD and PIGD, explicating neuroanatomical differences underlying these diverse clinical presentations. Methods: This study analyzed WM and GM microstructures using neurite orientation dispersion and density imaging (NODDI). Totals of 74 patients with PD and 47 age- and sex-matched healthy controls (HCs) were included. Tract-based spatial statistics (TBSS) and GM-based spatial statistics (GBSS) were applied to evaluate NODDI-derived metrics across groups. Results: A total of 24 TD patients (40.0%) and 36 PIGD patients (60.0%) were included for TBSS. In WM, PIGD showed a higher orientation dispersion index (ODI) in corona radiata compared to TD, and a lower neurite density index (NDI) in multiple WM tracts than HCs [P Conclusions: PIGD exhibited more extensive cerebral microstructural alterations than TD, and the microstructures showed significant cognitive correlations. NODDI-derived metrics may serve as potential biomarkers for cognitive and motor symptom assessment in PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.