ArticleQuantitative imaging in medicine and surgery2025
Utility of quantitative contrast-enhanced ultrasound: a valuable prediction for capsule invasion assessment in papillary thyroid cancer.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Development and validation of a multimodal predictive model based on clinical, biochemical, and quantitative dual-energy CT parameters: for predicting the benignity and malignancy of thyroid nodules.Frontiers in endocrinology · 2026Article
- Predictive value of conventional ultrasonographic features combined with clinical factors for capsular invasion in papillary thyroid carcinoma with Hashimoto's thyroiditis.American journal of cancer research · 2026Article
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6 authors.
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Abstract
Background: Papillary thyroid cancer (PTC) patients with capsule invasion have a risk of poor clinical outcomes. The aim of this study was to assess the diagnostic accuracy of quantitative contrast-enhanced ultrasound (CEUS) for detecting capsule invasion and identifying the relationship between capsule invasion and sonographic features of PTC. Methods: Patients confirmed as having PTC underwent conventional ultrasound (US) and CEUS examinations. The conventional US and qualitative CEUS features of the PTC nodules and capsule invasion were evaluated and classified separately. The accuracy of conventional US and qualitative CEUS in predicting capsule invasion was compared separately. Moreover, quantitative parameters were analyzed in different groups. The presence or absence of capsule invasion and cervical lymph node metastasis (LNM) was confirmed by the pathological results. Results: The study finally included 107 patients with 109 PTC nodules. A total of 58 (53.2%) of PTC nodules had no capsule invasion, whereas the remaining 51 had capsule invasion [including 19 patients with extracapsular extension (ECE)]. A significant difference was found in nodules with non-capsule invasion, single capsule invasion, and ECE between the LNM and non-LNM groups (χ Conclusions: Compared with conventional US and qualitative CEUS, quantitative CEUS is a more reliable and objective imaging method to predict capsule invasion of PTC.
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