ArticleQuantitative imaging in medicine and surgery2025
Age-related bone mass and body composition dynamics in female cynomolgus monkeys: dual-energy X-ray absorptiometry insights for osteoporosis etiology.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Osteoporosis, characterized by reduced bone mass and increased fracture risk, is a major global health burden. Nonhuman primates, particularly female cynomolgus monkeys, are critical preclinical models due to their skeletal and hormonal similarity to humans. Dual-energy X-ray absorptiometry (DXA) is the gold standard for measuring bone mineral density (BMD) and body composition. However, data on age-related changes in these metrics in cynomolgus monkeys are inconsistent, and the relationship between body composition and BMD remains debated and understudied in this model. The objectives of this study were to delineate the age-dependent trends in bone mass and body composition and to evaluate the impact of body composition on bone mass. This study aims to furnish a data reference for experiments involving bone mass and body composition in cynomolgus monkeys as a disease model. Methods: A cohort of 112 healthy female cynomolgus monkeys was stratified into four age-based groups. DXA scans were conducted to ascertain total body bone mass, subcranial bone mass, spine BMD (BMDs), central region-of-interest bone mineral density (BMD Results: In female cynomolgus monkeys ≤10 years of age, bone mass parameters showed a significant increase with age. Beyond the age of 10 years, BMDs remained stable with age, while total body BMD (BMD Conclusions: The bone mass and body composition data of female cynomolgus monkeys across different age groups serve as a valuable reference for studies employing female cynomolgus monkeys as animal models. BMD
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