Evidence map›Paper›PMID 41367717›Full record

SynthesisFrontiers in toxicology2025

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis.

Michael Ben Okon, Ilemobayo Victor Fasogbon, Dominic Swase, Reuben Samson Dangana, Wusa Makena, Vivian Onyinye Ojiakor, Ekom Monday Etukudo, Joan Chebet, Angela Mumbua Musyoka, Sandra Etumah Ifie and 11 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Michael Ben Okon *Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Ilemobayo Victor FasogbonDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Dominic SwaseDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Reuben Samson DanganaDiscipline of Genetics, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.
Wusa MakenaDepartment of Human Anatomy, Kampala International University, Bushenyi, Uganda.
Vivian Onyinye OjiakorDepartment of Human Anatomy, Kampala International University, Bushenyi, Uganda.
Ekom Monday EtukudoDepartment of Human Anatomy, Kampala International University, Bushenyi, Uganda.
Joan ChebetDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Angela Mumbua MusyokaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Sandra Etumah IfieDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Herbert MbyemeireDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Solomon Adomi MbinaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Okechukwu Paul-Chima UgwuDepartment of Publication and Extension, Kampala International University, Bushenyi, Uganda.
Augustine OviosunDepartment of Human Anatomy, Kampala International University, Bushenyi, Uganda.
Ibe Micheal UsmanDepartment of Human Anatomy, Kampala International University, Bushenyi, Uganda.
Josiah Eseoghene IfieDepartment of Science, Valley University of Science and Technology, Bushenyi, Uganda.
Loganathan RangasamyCentre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology, Vellore, India.
Olubukola Sinbad OlorunnisolaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Philippe MounmbegnaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.
Sana NoreenUniversity Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan.
Patrick Maduabuchi AjaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Bushenyi, Uganda.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, impairs male reproductive health via oxidative stress, hormonal dysregulation, and hypothalamic-pituitary-gonadal (HPG) axis disruption. Flavonoids, widely present in plant-derived foods and medicinal herbs, possess antioxidant and steroidogenic modulatory properties that may counteract BPA toxicity, yet preclinical findings remain inconsistent. This study aims to systematically evaluate and quantitatively synthesize preclinical evidence on the protective effects of flavonoids against BPA-induced male reproductive toxicity. Methods: Using PRISMA 2020 guidelines, Web of Science, Scopus, and PubMed were searched up to September 2024. Eligible studies involved BPA exposure in male rodents with flavonoid co-treatment and reported reproductive endpoints. Hormonal and oxidative stress biomarkers were pooled using a random-effects model, expressed as standardized mean differences (SMDs), with heterogeneity assessed by I Results: BPA significantly reduced testosterone (SMD = -4.91), estradiol (SMD = -2.72), follicle-stimulating hormone (FSH) (SMD = -7.71), and luteinizing hormone (SMD = -5.54), while increasing malondialdehyde and reducing antioxidant enzymes (SOD, CAT, GPx, and GSH). Discussion: Flavonoid co-treatment significantly improved hormonal profiles and oxidative balance, with the greatest recovery in FSH. High heterogeneity (I

Indexed as

bisphenol Aendocrine disruptionflavonoidsmeta-analysisoxidative stresspreclinical studiesreproductive toxicity

Identifiers

PMID41367717
PMCPMC12682639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.