Evidence map›Paper›PMID 41367675›Full record

ArticleERJ open research2025

Impact of reference equations on lung function and outcomes in fibrotic interstitial lung disease.

Veronica Marcoux, Prosanta Mondal, Ayodeji Adegunsoye, Mary E Strek, Deborah Assayag, Jolene H Fisher, Nathan Hambly, Nasreen Khalil, Martin Kolb, Stacey D Lok and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Veronica MarcouxDepartment of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Prosanta MondalDepartment of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, SK, Canada.
Ayodeji AdegunsoyeSection of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA.
Mary E StrekSection of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA.
Deborah AssayagDepartment of Medicine, McGill University, Montreal, QC, Canada.
Jolene H FisherDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Nathan HamblyDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Nasreen KhalilDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Martin KolbDepartment of Medicine, McMaster University, Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-3837-1467
Stacey D LokDepartment of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Helene ManganasDépartement de Médecine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Sana VahidyDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
Christopher J RyersonDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Kerri A JohannsonDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Yet H KhorRespiratory Research@Alfred, Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-5434-9342
Austin ILD Registry, CARE-PF and UC-ILD Registry Investigators

Funding

Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic ClustersK23HL146942 · NHLBI · UNIVERSITY OF CHICAGO · PI ADEGUNSOYE, AYODEJI · 2020 to 2024
$810k
NHLBI NIH HHS K23 HL146942
6 · The paper itself

Abstract

Background: The impact of applying different lung function reference equations and interpretation methods in fibrotic interstitial lung disease (ILD) is poorly understood. We aimed to evaluate disease severity classification, trajectories and prognostic significance of percent-predicted and z-scores of forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide ( Methods: Serial lung function measurements of 5026 patients from three prospective registries were used to calculate percent-predicted and z-scores using 2012- and 2023-GLI FVC reference equations and 2017-GLI Results: Baseline FVC and Conclusions: Use of different lung function reference equations and interpretation methods may impact disease severity classification and longitudinal trajectory in patients with fibrotic ILD, although prognostic significance is similar, except for 2023-GLI FVC in non-White patients.

Identifiers

PMID41367675
PMCPMC12683590

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.