Evidence map›Paper›PMID 41367648›Full record

ArticleERJ open research2025

Mucus plugs on CT and small airway pathology in COPD.

Francesca Polverino, Ruchita Borgaonkar, Christine Cong, David Sanz-Rubio, Alan Waich, Wei Wang, Sophia Mettler, Joshua Malo, Joselyn Rojas-Quintero, Alejandro A Diaz

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francesca PolverinoPulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.ORCID https://orcid.org/0000-0001-9686-5698
Ruchita BorgaonkarPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0009-0003-2947-2757
Christine CongPulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
David Sanz-RubioPulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Alan WaichPulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Wei WangSleep Medicine and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sophia MettlerDepartment of Medicine, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-7553-1346
Joshua MaloPulmonary and Critical Care Medicine, Department of Medicine, University of Arizona, Tucson, AZ, USA.
Joselyn Rojas-QuinteroPulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Alejandro A DiazPulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5037-2919

Funding

Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2M
Understanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7M
Clinical implications and Proteomics of Bronchiectasis Progression in SmokersR01HL173017 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Alejandro Diaz, Raul San Jose Estepar · 2024 to 2026
$2.6M
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolismR01HL171622 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Francesca Polverino · 2024 to 2026
$2.2M
NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL164824NHLBI NIH HHS R01 HL171622NHLBI NIH HHS R01 HL173017
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41367648
PMCPMC12683592

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.