Evidence map›Paper›PMID 41367638›Full record

ArticleBeilstein journal of organic chemistry2025

Chemoenzymatic synthesis of the cardenolide rhodexin A and its aglycone sarmentogenin.

Fuzhen Song, Mengmeng Zheng, Dongkai Wang, Xudong Qu, Qianghui Zhou

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fuzhen SongEngineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular Sciences, The Institute for Advanced Studies, TaiKang Center for Life and Medical Sciences and State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, 430072, China.
Mengmeng ZhengSchool of Life Sciences, Shanghai University, Shanghai, 200444, China.
Dongkai WangEngineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular Sciences, The Institute for Advanced Studies, TaiKang Center for Life and Medical Sciences and State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, 430072, China.
Xudong QuState Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0002-3301-8536
Qianghui ZhouEngineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular Sciences, The Institute for Advanced Studies, TaiKang Center for Life and Medical Sciences and State Key Laboratory of Metabolism and Regulation in Complex Organisms, Wuhan University, Wuhan, 430072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report a concise chemoenzymatic synthesis of the cardenolide rhodexin A in 9 steps and the first protecting-group-free synthesis of its aglycone sarmentogenin in 7 steps from 17-deoxycortisone. The synthesis features a scalable enzymatic C

Indexed as

cardiac glycosideschemoenzymatic synthesisC–H hydroxylationMukaiyama hydrationprotecting-group-free synthesis

Identifiers

PMID41367638
PMCPMC12684428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.