Evidence map›Paper›PMID 41367627›Full record

ArticleRegenerative biomaterials2025

Microporous structures on mineralized collagen mediate bone restoration by promoting nucleolin secretion to induce macrophage M2 polarization.

Jun Li, Yujiao Liu, Chunxiu Meng, Yujue Zhang, Yurun Luan, Kun Liu, Lina Zhang, Fengzhen Liu, Xin Luo, Bin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun LiLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Yujiao LiuLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Chunxiu MengLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Yujue ZhangLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Yurun LuanLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Kun LiuLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Lina ZhangLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Fengzhen LiuLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.ORCID https://orcid.org/0000-0002-1192-8002
Xin LuoLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.
Bin ZhangLiaocheng People's Hospital, Liaocheng Hospital Affiliated Shandong First Medical University, Liaocheng 252000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects rehabilitation is one of the difficulties in oral clinical practice. Implanted biomaterials have pivotal effects on the regeneration in critical bone defects, but the immunologic reactions arising from their entering into the body are difficult to control. Biomaterials characteristics can effect the immune response, and thus, interfere with the skeletal system. Our previous study found that microporous structures on mineralized collagen (MC) modulated macrophage polarization in bone immune response thereby promoting osteogenic differentiation of osteoblasts. However, the role of MC with various microporous structures in guiding bone rejuvenation

Indexed as

bone restorationmacrophage polarizationmicroporous structuresmineralized collagenNCL expression

Identifiers

PMID41367627
PMCPMC12684704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.