Evidence map›Paper›PMID 41367614›Full record

ReviewFrontiers in genetics2025

Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations.

Jing Chen, XiaoLing Chen, Fei He

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jing ChenCollege of Stomatology, Xi'an Jiaotong University, Xi'an, China.
XiaoLing ChenDepartment of Neurology, School of medicine, Sichuan provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Fei HeCollege of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP) is a severe inflammatory condition that frequently leads to systemic inflammatory response syndrome and multiple organ failure. Despite the increasing occurrence, targeted therapies remain unavailable. CircRNAs have recently been implicated in AP pathogenesis, regulating biological processes such as apoptosis, pyroptosis, and inflammation through mechanisms including miRNA sponging, protein scaffolding, and translation. Their disease-specific roles make them promising candidates for clinical translation. This review highlights the potential of circRNAs as novel diagnostic tools and therapeutic targets in AP, aiming to guide future advancement of innovative biomarkers and therapeutic strategies.

Indexed as

acute pancreatitisbiomarkerchronic pancreaititisCircRNAstherapeutic tool

Identifiers

PMID41367614
PMCPMC12682810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.