Evidence map›Paper›PMID 41367532›Full record

ArticleTranslational pediatrics2025

Efficacy of omalizumab in the treatment of STAT3 loss-of-function mutations associated with autosomal dominant hyperimmunoglobulin E syndrome-a case report.

Hongwei Li, Yanhong Wang, Ying Tao, Shangzhi Wu, Qingyun Xu, Chengyu Lu, Zhanhang Huang, Yingying Zhai, Dehui Chen

Abstract readCase Reports
In one paragraph

Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongwei LiDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yanhong WangDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ying TaoDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shangzhi WuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qingyun XuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chengyu LuDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhanhang HuangDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yingying ZhaiDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dehui ChenDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autosomal dominant signal transducer and activator of transcription 3 ( Case Description: We report two cases of AD-HIES caused by Conclusions: The combination of omalizumab with conventional therapy may contribute to improved pulmonary and dermatological symptoms in patients with AD-HIES resulting from

Indexed as

case reporthyper-immunoglobulin E syndrome (hyper-IgE syndrome)omalizumabprimary immunodeficiencySignal transducer and activator of transcription 3 loss-of-function (STAT3 LOF)

Identifiers

PMID41367532
PMCPMC12683399

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.