ArticleCureus2025
A Study of Adverse Drug Reactions to Antiepileptic Drugs in Pediatric Epileptic Patients From North India.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
objectivesThe primary objective of this study was to evaluate the various adverse drug reactions (ADRs) associated with antiepileptic drugs in children. The secondary objective was to analyze the distribution of these ADRs according to gender, age group, type of epilepsy, and treatment modality. MATERIALS AND
methodsAn observational cross-sectional study was conducted in the pediatric outpatient department of a tertiary care hospital. A total of 100 eligible patients, who fulfilled the inclusion and exclusion criteria, were enrolled in the study after obtaining informed consent. The prescription details and ADRs were collected using a pre-designed proforma and the Pediatric Epilepsy Side-effect Questionnaire, respectively. The collected data were then analyzed using descriptive statistics and the chi-square test, where appropriate. The p-value <0.05 was considered statistically significant.
resultsA total of 67 ADRs were reported in 42 participants, predominantly in males (71.43%). Polytherapy (75%) was associated with a higher number of ADRs (p=0.002). Patients treated with valproate (monotherapy group) and valproate with clobazam (polytherapy group) reported a greater number of ADRs (57.14%, 72.73%).
conclusionsThe study highlights that ADRs are more common in patients on conventional drugs like valproate, either as monotherapy or polytherapy. Use of newer drugs by physicians and reporting of ADRs by patients should be encouraged for the comprehensive management of childhood epilepsy.
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