ReviewCureus2025
Redox Imbalance in Coronary Artery Bypass Grafting: The Clinical Significance of Aminothiols.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From Exposure to Outcome: Air Pollution-Induced Oxidative Stress as a Determinant of Early and Late Outcomes After Coronary Artery Bypass Grafting.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery bypass grafting (CABG) is a vital intervention for severe coronary artery disease, yet it induces significant oxidative stress, contributing to postoperative complications and long-term cardiovascular risks. Aminothiols, including glutathione, homocysteine, cysteine, and cysteinylglycine, are key regulators of redox homeostasis, making them promising biomarkers for assessing oxidative stress in CABG patients. This narrative review explores their biochemical roles, measurement techniques, and associations with clinical outcomes. Glutathione mitigates reactive oxygen species (ROS) through the glutathione redox cycle, while elevated homocysteine promotes oxidative damage and inflammation, linked to complications like atrial fibrillation and acute kidney injury. Cysteine and cysteinylglycine further support redox balance, with their dysregulation reflecting perioperative stress. Studies demonstrate that altered aminothiol levels pre- and post-CABG correlate with adverse outcomes, including myocardial injury, graft restenosis, and major adverse cardiovascular events. Advanced analytical methods like high-performance liquid chromatography and liquid chromatography-mass spectrometry enable precise aminothiol quantification, although variability and lack of standardization pose challenges. Therapeutic interventions, such as N-acetylcysteine and folate supplementation, show potential to modulate aminothiol levels and reduce oxidative stress. Despite these insights, gaps in longitudinal data and assay standardization limit clinical adoption. Future research should focus on standardized protocols, large-scale studies, and metabolomics to integrate aminothiols into personalized medicine, enhancing risk stratification and therapeutic strategies for improved CABG outcomes. Overall, this narrative review synthesizes available data on aminothiols and oxidative stress in CABG, with the objective of identifying knowledge gaps and potential pathways for translational and clinical application.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.