Evidence map›Paper›PMID 41367412›Full record

ArticleAntibody therapeutics2025

Assessing the therapeutic potential of a panel of novel VCAM-1 antibodies using microfluidic and three-dimensional

Jessica R Pickett, Lucia F Zacchi, Binura Perera, Yuao Wu, Hang Thu Ta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibody therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica R PickettSchool of Environment and Science, Griffith University, 170 Kessels Road, Nathan, Queensland 4111, Australia.
Lucia F ZacchiSchool of Chemistry and Molecular Biosciences, The University of Queensland, 280-284 Sir Fred Schonell Drive, St Lucia, Queensland 4072, Australia.
Binura PereraSchool of Environment and Science, Griffith University, 170 Kessels Road, Nathan, Queensland 4111, Australia.
Yuao WuSchool of Environment and Science, Griffith University, 170 Kessels Road, Nathan, Queensland 4111, Australia.
Hang Thu TaSchool of Environment and Science, Griffith University, 170 Kessels Road, Nathan, Queensland 4111, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Antibodies against vascular cell adhesion molecule (VCAM)-1 represent an attractive strategy for atherosclerosis and cardiovascular disease management due to their ability to selectively block leukocyte-endothelial interactions involved in inflammatory cell recruitment. Herein, seven novel anti-VCAM-1 monoclonal antibodies (mAbs) generated from phage display biopanning were tested using a series of Methods and Results: We assessed the inhibitory effects of the test antibodies on cell adhesion and transmigration using a series of Conclusion: These results indicate that our novel anti-VCAM-1 mAbs can effectively inhibit monocyte adhesion and transmigration

Indexed as

antibody therapyatherosclerosisendothelial cellmonocytevascular cell adhesion moleculeVCAM-1

Identifiers

PMID41367412
PMCPMC12683022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.