Evidence map›Paper›PMID 41367410›Full record

ArticleJournal of oral microbiology2025

Geographic signatures in the oral resistome: a comparative metagenomic analysis of healthy individuals from Thailand and Norway.

Supathep Tansirichaiya, Kittikun Songsomboon, Johannes Wigand, Endre Winje, Nichamon Chaianant, Wasawat Leartsiwawinyu, Mohammed Al-Haroni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Supathep TansirichaiyaDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-4445-8529
Kittikun SongsomboonClimate Change Cluster, University of Technology Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-3189-2318
Johannes WigandDepartment of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.
Endre WinjeDepartment of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.
Nichamon ChaianantResearch Unit in Mineralized Tissue Reconstruction and Faculty of Dentistry, Thammasat University, Pathumthani, Thailand.ORCID https://orcid.org/0000-0003-4742-4348
Wasawat LeartsiwawinyuDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0009-0007-3280-7625
Mohammed Al-HaroniDepartment of Clinical Dentistry, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway.ORCID https://orcid.org/0000-0002-7347-7016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The oral cavity is an important yet understudied reservoir of antimicrobial resistance genes (ARGs), potentially shaped by geographic variation in antibiotic usage. Objective: To compare the oral resistomes of healthy adults from Thailand and Norway, two countries with contrasting antimicrobial use practices, using shotgun metagenomic sequencing. Design: Stimulated saliva samples were collected from healthy adults in Thailand ( Results: Thai samples exhibited significantly greater ARG richness, evenness, and diversity ( Conclusions: These results reveal distinct geographic signatures in the oral resistome that are not fully explained by microbiome structure, reflecting the influence of local ecological and societal factors, including antimicrobial exposure. The findings highlight the oral cavity as a dynamic ARG reservoir and support its inclusion in regional antimicrobial resistance surveillance to inform public health strategies.

Indexed as

Antimicrobial resistance geneHuman oral cavityOral microbiomeOral resistomeSaliva metagenome

Identifiers

PMID41367410
PMCPMC12683769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.