Evidence map›Paper›PMID 41367406›Full record

ArticleFrontiers in dental medicine2025

Periodontitis biomarkers through thermal desorption-gas chromatography-mass spectrometry analysis.

Qin Liang, Yanling Zhang, Xiaoli Zhang, Yizhou Liu, Shaojia Xu, Yajuan Lei, Xiaodong Li, Chao Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qin LiangDepartment of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China.
Yanling ZhangDepartment of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China.
Xiaoli ZhangShimadzu (China) Co., LTD. China Innovation Center, Beijing, China.
Yizhou LiuDepartment of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China.
Shaojia XuDepartment of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China.
Yajuan LeiShimadzu (China) Co., LTD. China Innovation Center, Beijing, China.
Xiaodong LiShimadzu (China) Co., LTD. China Innovation Center, Beijing, China.
Chao YuanDepartment of Preventive Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Periodontitis is a growing public health concern worldwide. Salivary volatile metabolites have emerged as promising biomarkers for the diagnosis of periodontal disease. However, research on the collection and identification of these metabolites in periodontitis patients remains limited. Objectives: To explore methods for collecting and identifying salivary volatile metabolites in periodontitis patients and investigate their potential as biomarkers for diagnosing periodontal disease. Method: Oral exhaled breath and saliva samples were collected from 115 periodontitis patients and 35 healthy individuals, divided into four cohorts. The discovery cohort (Periodontitis: Result: A total of 78 Volatile organic compounds (VOCs) were detected by TD-GC-MS, with 14 differential VOCs identified. A diagnostic model was established using cyclohexanone, styrene, and ethanol, yielding a combined AUC of 0.8237. These metabolites were also detected in saliva by SPME-GC-MS, with cyclohexanone showing higher expression in the periodontitis group ( Conclusion: We developed a novel method for analyzing salivary volatile metabolites using TD-GC-MS, demonstrating potential for periodontitis diagnosis. Cyclohexanone is identified as a potential biomarker for periodontitis, and the caprolactam degradation pathway may play a significant role in future studies on oral microbiota dysbiosis in periodontitis patients.

Indexed as

biomarkeroralexhaled breathperiodontitissalivary volatile metabolitesTD-GC-MS

Identifiers

PMID41367406
PMCPMC12682746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.