Evidence map›Paper›PMID 41367377›Full record

ArticleFrontiers in cardiovascular medicine2025

Impact of postoperative delirium on long-term neurologic and neuropsychiatric outcome after cardiac surgery or percutaneous valve replacement-a prospective observational study.

Maike Schmidt, Lukas Hinken, Johannes Teller, Maria Magdalena Gabriel, Svea-Dorothee Schimmelpfennig, Ralf Lichtinghagen, Christine Fegbeutel, Andreas Schäfer, Karin Weissenborn, Carolin Jung and 1 more

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maike Schmidt *Department of Neurology, Hannover Medical School, Hanover, Germany.
Lukas Hinken *Department of Anesthesiology, Hannover Medical School, Hanover, Germany.
Johannes TellerDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Maria Magdalena GabrielDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Svea-Dorothee SchimmelpfennigDepartment of Anesthesiology, Hannover Medical School, Hanover, Germany.
Ralf LichtinghagenDepartment of Clinical Chemistry, Hannover Medical School, Hanover, Germany.
Christine FegbeutelDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany.
Andreas SchäferDepartment of Cardiology and Angiology, Hannover Medical School, Hanover, Germany.
Karin WeissenbornDepartment of Neurology, Hannover Medical School, Hanover, Germany.
Carolin JungDepartment of Anesthesiology, Hannover Medical School, Hanover, Germany.
Hans WorthmannDepartment of Neurology, Hannover Medical School, Hanover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients undergoing cardiac surgery or percutaneous valve replacement may experience long-term neurologic and neuropsychiatric complications. The impact of postoperative delirium (POD) on these long-term complications remains controversial. We intended to illustrate the neurological and neuropsychiatric outcome associated with the occurrence of POD in patients undergoing elective cardiac surgery or percutaneous valve replacement. Methods: We included 179 patients who underwent elective cardiac surgery or percutaneous valve replacement. Patients were evaluated postoperatively for delirium status. Neurological (score A) and neuropsychiatric (score B) outcomes were assessed using a structured examination protocol and interview at 1 year postoperatively and combined into a composite neurological and neuropsychiatric score (score A + B). Cognitive function was examined using the Montreal Cognitive Assessment (MoCA). Depression, fatigue and quality of life were assessed using the Beck's Depression Inventory (BDI), the Fatigue Impact Scale (FIS) and the Short-Form Health Survey (SF-12). Clinical outcome was assessed using the Barthel-Index (BI) and Frailty Index (FI). All data were collected prospectively. Results: One year after cardiac surgery or percutaneous valve replacement, a high number of patients suffered from neurological and neuropsychiatric symptoms with depressive symptoms ( Conclusions: POD in patients undergoing cardiac surgery or percutaneous valve replacement was independently associated with worse long-term neurological and neuropsychiatric outcome. POD may be a relevant prognostic marker indicating the need for specific follow-up services, whereas other clinical parameters were not predictive of outcome.

Indexed as

cardiac surgerycognitive functiondepressionneurologic and neuropsychiatric outcomepercutaneous valve replacementpostoperative delirium

Identifiers

PMID41367377
PMCPMC12682873

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