Evidence map›Paper›PMID 41367307›Full record

ArticleACS chemical neuroscience2026

(±)-2-Cyclohexyl-5-methoxy-2H-chromene, a Synthetic 5-Methoxyflavone Derivative, Is a Selective DNA Polymerase-β Inhibitor with Neuroprotective Activity against β-Amyloid Toxicity.

Salvatore Guccione, Sara Merlo, Silvia Tagliapietra, Matteo Pappalardo, Arianna Binello, Alessandro Barge, Livia Basile, Maria Angela Sortino, Giancarlo Cravotto, Agata Copani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Salvatore GuccioneDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.
Sara MerloDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-6558-9800
Silvia TagliapietraDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Matteo PappalardoDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.
Arianna BinelloDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Alessandro BargeDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0003-4638-6634
Livia BasileDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0001-8046-6393
Maria Angela SortinoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Giancarlo CravottoDepartment of Drug Science and Technology, University of Torino, 10125 Torino, Italy.ORCID 0000-0001-7574-7350
Agata CopaniDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-3730-2590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA polymerase-β (DNA pol-β) plays a critical role in β-amyloid-induced neurodegeneration by mediating aberrant DNA replication in postmitotic neurons. In previous work, we demonstrated that 5-methoxyflavone inhibits DNA pol-β, though computational analyses suggested potential binding to the primase p58 subunit. Through molecular modeling, here, we designed (

Indexed as

Amyloid beta-PeptidesBenzopyransDNA Polymerase betaEnzyme InhibitorsNeuroprotective AgentsPeptide FragmentsAnimalsFlavonesHumansMiceNeuronsRatsAmyloid beta-PeptidesBenzopyransDNA Polymerase betaEnzyme InhibitorsFlavonesNeuroprotective AgentsPeptide FragmentsDNA polymerase-ßneuronal apoptosisneuronal cell cycle reactivationneuroprotectionß-amyloid

Identifiers

PMID41367307
PMCPMC12784329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.