ArticleRenal failure2025
Association between low-density lipoprotein cholesterol and coronary plaque progression in non-dialysis chronic kidney disease: a retrospective cohort study.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
This study aimed to investigate the characteristics of coronary plaque progression in non-dialysis chronic kidney disease (CKD) patients, particularly focusing on the association between low-density lipoprotein cholesterol (LDL-C) levels and plaque progression across different stages of CKD. Two hundred ninety-two patients with CKD who underwent percutaneous coronary intervention during their initial coronary angiography and received follow-up angiography within 2 years were enrolled. These patients were classified into plaque progression and non-progression groups using quantitative coronary angiography analysis. Our findings demonstrate that patients with coronary plaque progression exhibited higher LDL-C levels and lower estimated glomerular filtration rate (eGFR). Smooth curve and logistic regression analysis revealed a gradual increase in the probability of plaque progression with elevated LDL-C levels, each 1 mmol/L increase in LDL-C was associated with a 2.63-fold higher risk of plaque progression in patients with eGFR of 45-60 mL/min/1.73 m
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