Evidence map›Paper›PMID 41367119›Full record

ArticleSmall methods2026

Nanopore Trap for Label-Free Fingerprinting of Surface-modified Single Nanoparticles.

Nianduo Cai, Tzu-Heng Chen, Yunfei Teng, Akhil Sai Naidu, Aleksandra Radenovic

Abstract read
In one paragraph

Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nianduo CaiLaboratory of Nanoscale Biology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0002-5905-7664
Tzu-Heng ChenLaboratory of Nanoscale Biology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0001-7994-8950
Yunfei TengLaboratory of Nanoscale Biology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0003-2372-2340
Akhil Sai NaiduLaboratory of Nanoscale Biology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0009-0006-9794-7621
Aleksandra RadenovicLaboratory of Nanoscale Biology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.ORCID https://orcid.org/0000-0001-8194-2785

Funding

HORIZON EUROPE European Research Council 101020445Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 200021_192037Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung CRSII5_193740
6 · The paper itself

Abstract

Label-free characterization of nanoparticle surface functionalization at single-particle resolution is essential for a wide range of applications. Solid-state nanopore sensing provides a direct electrical readout that is intrinsically sensitive to the size, surface layer, and interfacial chemistry of single particles in liquid environments. The trapping-based nanopore sensing regime further enables probing surface-dependent particle-pore interactions with extended observation time. Here, a solid-state nanopore trap-based fingerprinting method is presented to differentiate single nanoparticles with distinct surface modifications. The method combines a "trap-release" measurement protocol with a multi-metric analysis workflow that extracts blockade distributions, sub-level statistics and frequency-domain signatures from trapping events, and constructs a unique fingerprint for each particle species. Applied to silica cores (≈25-30 nm) functionalized with APTES, NHS-PEG

Indexed as

NanoparticlesNanoporesSilicon DioxideStreptavidinSurface PropertiesSilicon DioxideStreptavidinnanopore trappingsingle‐particle sensingsolid‐state nanopore

Identifiers

PMID41367119
PMCPMC12893298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.