Evidence map›Paper›PMID 41367116›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System.

Uththara M C Rathnaweera, Olivia Sam, Karolis Norvaisa, Sarah R Marshall, Randima D De Silva Weerakonda Arachchige, Matúš Chvojka, Hennie Valkenier, Nathalie Busschaert

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uththara M C RathnaweeraDepartment of Chemistry, Tulane University, 6400 Freret St, New Orleans, LA, 70118, USA.
Olivia SamDepartment of Chemistry, Tulane University, 6400 Freret St, New Orleans, LA, 70118, USA.
Karolis NorvaisaEngineering of Molecular NanoSystems, École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, Brussels, 1050, Belgium.ORCID 0000-0003-3219-8739
Sarah R MarshallDepartment of Chemistry, Tulane University, 6400 Freret St, New Orleans, LA, 70118, USA.
Randima D De Silva Weerakonda ArachchigeDepartment of Chemistry, Tulane University, 6400 Freret St, New Orleans, LA, 70118, USA.
Matúš ChvojkaEngineering of Molecular NanoSystems, École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, Brussels, 1050, Belgium.ORCID 0000-0002-3485-6064
Hennie ValkenierEngineering of Molecular NanoSystems, École Polytechnique de Bruxelles, Université Libre de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, Brussels, 1050, Belgium.ORCID 0000-0002-4409-0154
Nathalie BusschaertDepartment of Chemistry, Tulane University, 6400 Freret St, New Orleans, LA, 70118, USA.ORCID 0000-0002-3612-3382

Funding

Fonds de la Recherche Scientifique - FNRSNational Science Foundation #2108699National Science Foundation #2216220
6 · The paper itself

Abstract

Nucleotides such as cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) are central to many cellular processes, but their highly hydrophilic and charged nature prevents passive permeation across lipid bilayers. Here, we report the first example of facilitated transport of cAMP and AMP across liposome membranes using a neutral two-component system at physiological pH. This system pairs a synthetic anionophore targeting the phosphate group with a thymine derivative to boost transport efficiency. Liposome-based fluorescence and

Indexed as

Adenosine MonophosphateCyclic AMPBiological TransportLipid BilayersLiposomesAdenosine MonophosphateCyclic AMPLipid BilayersLiposomesAnionophorecAMPNucleotideSupramolecular chemistryTransmembrane transport

Identifiers

PMID41367116
PMCPMC12828476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.