ArticleMedicine2025
A rare case of littoral cell angioma with paroxysmal nocturnal hemoglobinuria.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleWe report a rare case of littoral cell angioma (LCA) in a patient with paroxysmal nocturnal hemoglobinuria (PNH). To our knowledge, this is the first report of these 2 rare conditions occurring together, which may help clarify their relationship and its importance in clinical practice. PATIENT CONCERNS: A 38-year-old man had recurrent anemia and dark brown urine, accompanied by abdominal pain that worsened over time, which required several hospital visits and long-term follow-up. DIAGNOSES: Follow-up scans showed progressive splenomegaly with multiple nodules. In combination with histopathology and immunohistochemistry results (CD31, CD34, and ERG positive; Ki-67 around 5%), these findings confirmed a final diagnosis of LCA in a patient with previously diagnosed PNH.
interventionsThe patient received treatment with oral prednisone, sodium bicarbonate, and vitamin E for PNH. As the splenic lesions enlarged and blood counts worsened, he subsequently underwent laparoscopic splenectomy in February 2025. OUTCOMES: After surgery, both LCA and anemia concurrently resolved, with normalization of hematologic parameters and resolution of abdominal symptoms. LESSONS: This case suggests a potential association between LCA and PNH. Splenectomy provided dual benefits by treating the splenic tumor and improving hemolysis. Given the possible risk of malignant transformation, long-term follow-up is recommended.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.