Observational studyMedicine2025
Potential ocular health benefit of short-term omega-3 fatty acids supplementation on the ocular tear film: An observational study.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immune inflammatory targets and anti-inflammatory therapy in dry eye disease.International ophthalmology · 2026Review
- An Overview of Rheumatoid Arthritis-Associated Dry Eye Disease, Scleritis, and Peripheral Ulcerative Keratitis.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Omega-3 fatty acids can reduce inflammation and, as a result, decrease the production of inflammatory mediators. The study aimed to evaluate the short-term effects of omega-3 fatty acid supplementation on the tear film. Fifty subjects aged 18 to 27 years were recruited. All subjects received 2 soft gels of molecularly distilled omega-3 fatty acids for 3 consecutive days. A control age-matched group of 50 subjects was included for comparison. The standard patient evaluation of eye dryness (SPEED) questionnaire was completed, followed by the noninvasive tear breakup time (NITBUT), tear meniscus height (TMH), and tear ferning (TF) tests. The first measurements were taken before the supplement was consumed, and the second measurements were taken 24 hours after the third dose of omega-3 fatty acids was administered. The control group subjects did not get omega-3, with measurements on days 1 and 4. Significant (Wilcoxon signed-rank test) differences were found in the median scores of the SPEED (P <.001), NITBUT (P <.001), and TF (P = .040) before and after the consumption of omega-3 fatty acids. However, consuming omega-3 fatty acids showed no significant difference in TMH score. For the control group, no significant differences were observed in the SPEED (P = .093), NITBUT (P = .149), TMH (P = .831), and TF (P = .567) scores between days 1 and 4. The oral consumption of omega-3 fatty acids over 3 consecutive days significantly improved the comfort, stability, and quality of the ocular tear film. However, no significant change was observed in tear volume after the consumption of omega-3 fatty acids. Further research is still necessary to verify the general applicability of the findings and to address the existing limitations.
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Registered trials
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