Trial reportMedicine2025
Effectiveness of a porcine-derived acellular dermal matrix for peri-implant soft-tissue augmentation: A prospective study.
Trial report in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adequate peri-implant soft tissue is essential for functional and aesthetic success. Autologous grafts are effective but limited by morbidity. This study assessed a porcine-derived acellular dermal matrix (PADM) for anterior maxillary soft-tissue augmentation. 31 patients with implants in the anterior maxilla underwent PADM grafting. Keratinized gingival thickness, width (KGW), zenith-incisal edge distance, and shrinkage rate were measured at baseline (T0), immediate postoperative (T1), 1 month (T2), and 3 months (T3). Aesthetic outcomes were assessed with the pink aesthetic score, and pain with a numeric rating scale. Data were analyzed using Friedman and Wilcoxon signed-rank tests. keratinized gingival thickness increased from 0.69 ± 0.30 mm at T0 to 2.40 ± 0.63 mm at T1 (P < .001), decreasing to 1.55 ± 0.41 mm at T3 but remaining above baseline. KGW remained stable. Zenith-incisal edge distance showed significant differences among time points (χ² = 31.31, P < .001). Shrinkage rates were 16.1% (T1-T2) and 33.1% (T2-T3). Pink aesthetic score improved from 5.6 ± 2.1 to 6.8 ± 2.2 at 3 months (P < .05). Numeric rating scale pain declined from 2.7 ± 1.2 immediately post-op to 0.4 ± 0.5 after 1 week (P < .001). No complications occurred. PADM is a clinically effective and esthetically favorable option for peri-implant soft-tissue augmentation in the anterior maxilla. It offers acceptable long-term tissue stability and excellent patient tolerance. However, postoperative tissue shrinkage remains a concern, warranting further investigation in controlled comparative studies.
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