ArticleMedicine2025
Causal association between modifiable risk factors and aortic aneurysm and aortic dissection: A comprehensive Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Diet Quality, Physical Activity, and the Risk of Aortic Dissection-A Prospective Cohort Study.Journal of cardiovascular development and disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Aortic aneurysms (AA) and aortic dissection (AD) are life-threatening cardiovascular conditions. While epidemiological studies have suggested associations with modifiable risk factors, their causal nature remains unclear. This study aimed to explore the causal links between modifiable risk factors and risks of AA and AD using Mendelian randomization. A 2-sample Mendelian randomization approach was applied, utilizing genetic instrumental variables from genome-wide association studies with a significance threshold of P < 5 × 108. Summary data for AA and AD were obtained from 209,836 participants. Causal effect estimates were calculated for the 46 risk factors using inverse-variance-weighted models. Vigorous physical activity reduced the risk of AA, whereas alcohol consumption and smoking increased it. Obesity traits, including high body mass index, waist circumference, and body fat mass, were associated with a higher AA risk. High-density lipoprotein cholesterol (HDL-C) had a protective effect against AA, whereas low-density lipoprotein cholesterol (LDL-C) and triglycerides increased the risk of AA. Hypertension and high diastolic blood pressure significantly elevated the risk of both AA and AD, whereas type 2 diabetes appeared to be protective against AA. A diet rich in oily fish was found to protect against AD. Liver enzymes and sex hormones were not significantly associated with AA risk. This study identified causal relationships between modifiable risk factors and AA/AD risk, emphasizing the importance of physical activity, obesity management, and dietary adjustments in preventing aortic diseases. These findings provide insights into public health and clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.