Evidence map›Paper›PMID 41366744›Full record

ArticleBMC cardiovascular disorders2025

Combined influence of nutritional and inflammatory status on mortality in cancer survivors complicated with cardiovascular disease.

Yeshen Zhang, Yixuan Li, Xianglin Long, Yunshu Li, Ziyi Li, Shan Tu, Wenzhi Luo, Lixiong Zeng, Fei Ye, Zhihui Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yeshen Zhang *Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Yixuan Li *Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Xianglin LongDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Yunshu LiDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Ziyi LiDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Shan TuDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Wenzhi LuoDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Lixiong ZengDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China. zenglixiong@csu.edu.cn.
Fei YeDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China. Yefeixy3@csu.edu.cn.
Zhihui ZhangDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, 410013, China. zhangzhihui0869@csu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities of Central South University 2025ZZTS0309National Natural Science Foundation of China 82570448Scientific Research and Innovation Project of postgraduates in Hunan Province CX20250422
6 · The paper itself

Abstract

backgroundThe advanced lung cancer inflammation index (ALI) reflects systemic inflammatory and nutritional status, both of which are related to the prognosis of the disease. However, the prognostic value of ALI in cancer survivors with cardiovascular disease (CVD) remains unclear. This study was conducted to investigate the association of ALI with mortality in cancer survivors with CVD.

methodsThis study enrolled 955 cancer survivors with CVD from the National Health and Nutrition Examination Survey (NHANES, 1999–2018), and followed mortality status until December 31, 2019. Cox proportional hazards regression analysis and threshold effect analysis were applied to evaluate the relationship between ALI and all-cause, CVD-specific, and cancer-specific mortality. The prognostic value of ALI was further examined by time-dependent receiver operating characteristic (ROC) curve analysis.

resultsDuring a median follow-up period of 66.65 months, 490 all-cause deaths were observed, including 181 CVD-specific deaths and 121 cancer-specific deaths. After multivariate adjustment, ALI was inversely associated with all-cause, CVD-specific, and cancer-specific mortality in cancer survivors with CVD. Furthermore, L-shaped associations of ALI with mortality were discovered, with inflection points of 74.18 for all-cause and CVD-specific mortality and 55.50 for cancer-specific mortality. When the ALI was less than the inflection points, a 10-unit increase of ALI was associated with a 16%, 16%, and 25% decreased HR for all-cause, CVD-specific, and cancer-specific mortality, respectively. The time-dependent ROC curve analysis showed that the ALI had moderate predictive value for short- and long-term mortality.

conclusionThe ALI is a significant prognostic indicator of mortality for cancer survivors with CVD. The findings indicate the potential clinical value of monitoring and evaluating the ALI in preventing mortality in cancer survivors with CVD.

Indexed as

Cancer SurvivorsCardiovascular DiseasesInflammationNeoplasmsNutritional StatusAdultAgedCause of DeathFemaleHumansMaleMiddle AgedNutrition SurveysPrognosisRisk AssessmentRisk FactorsAdvanced lung cancer inflammation indexCancer survivorsCardiovascular diseaseMortalityPrognostic value

Identifiers

PMID41366744
PMCPMC12690814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.