ArticleLipids in health and disease2025
Relationship of admission uric acid to high density lipoprotein cholesterol ratio with unfavorable prognosis among acute ischemic stroke patients.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of serum uric acid to high density lipoprotein cholesterol ratio with stroke.Scientific reports · 2026Article
- Exploring the relationship between uric acid-to-HDL cholesterol ratio and vascular calcification: evidence from clinical, genetic, and network-based analyses.Frontiers in cardiovascular medicine · 2026Article
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6 authors.
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Abstract
backgroundAcute ischemic stroke (AIS) remains a major determinant for both mortality and enduring functional impairment. High density lipoprotein cholesterol (HDL) and Uric acid (UA) have opposing effects on oxidative stress and vascular protection. The UA/HDL ratio (UHR) may reflect systemic oxidative-lipid imbalance. This study examined whether admission UHR is linked to unfavorable prognosis among individuals with AIS.
methodsBetween October 2022 and September 2024, 822 consecutive AIS patients admitted to Bethune Hospital of Shanxi were retrospectively analyzed. Inclusion required first-ever AIS confirmed by imaging findings within 72 h. The principal endpoint was the functional status assessed at 90 days. Baseline demographics, clinical features, and laboratory values were collected. To account for confounding factors, the association of UHR with outcomes was analyzed through restricted cubic spline (RCS) models, multivariable logistic regression and subgroup analyses.
resultsAmong 822 patients, 262 (31.9%) had unfavorable outcomes. These patients exhibited higher UA, lower HDL, and elevated UHR. Multivariable analysis confirmed that UHR was independently associated with unfavorable outcomes (adjusted OR: 1.0021; P = 0.0013). Membership in the top UHR quartile conferred an approximately twofold higher risk compared with the bottom quartile (adjusted OR = 1.97). RCS models demonstrated a linear positive association, with consistent findings across subgroups defined by stroke severity, sex, smoking, alcohol use, hypertension, and diabetes.
conclusionsAdmission UHR is independently linked to unfavorable prognosis among individuals with AIS and holds promise as a simple, economical tool for early risk stratification and personalized management. Its use could support timely interventions and personalized management, contributing to improved patient outcomes and efficient allocation of healthcare resources. Prospective research is needed to validate its prognostic value and guide targeted interventions.
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