Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors.
Erik FernströmDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-0769-4602
Thomas Björk-ErikssonDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Pontus EricksonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Jan NymanDepartment of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Marie KalmDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Funding
AD Strategic Fund and the Alzheimer's Association ADSF-21-831376-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831377-CAD Strategic Fund and the Alzheimer's Association ADSF-21-831381-CAD Strategic Fund and the Alzheimer's Association ADSF-24-1284328-CAlzheimer's Drug Discovery Foundation 201809-2016862Anonymous donorBarncancerfondenBluefield ProjectCure Alzheimer's FundErling-Persson Family FoundationEuropean Partnership on Metrology NEuroBioStand, #22HLT07European Union Joint Program-Neurodegenerative Disease Research JPND2021-00694European Union's Horizon Europe Research and Innovation Program 860197 (MIRIADE)Familjen Rönströms StiftelseFrimurare Barnhus Foundations of GothenburgHjärnfonden #FO2022-0270HORIZON EUROPE Research and Innovation program 101053962Lions Cancer Fund of Western SwedenNational Institute for Health and Care Research University College London Hospitals Biomedical Research CentreOlav Thon FoundationStiftelsen för Gamla TjänarinnorStiftelsen Jubileumsklinikens Forskningsfond mot CancerSvenska LäkaresällskapetSwedish state under the ALF-agreement ALFGBG-71320Swedish state under the ALF-agreement ALFGBG-774991Swedish state under the ALF-agreement ALFGBG-819811Swedish state under the ALF-agreement ALFGBG-875691UK Dementia Research Institute UKDRI-1003Vetenskapsrådet 2019-02397Vetenskapsrådet 2022-01018Vetenskapsrådet 2023-00356
6 · The paper itself
Abstract
In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal fluid after irradiation; serum NfL correlated with cerebrospinal fluid values, apparently independent of blood-brain barrier function, whereas GFAP correlations were weaker. Although several patients developed brain metastases, linear mixed model results were consistent with an independent effect of radiotherapy on serum NfL and GFAP. Serum placental growth factor also rose and correlated with the albumin ratio. Our results support a radiotherapy-associated increase of NfL and GFAP in blood.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain. · full record | OpenQuestion