Evidence map›Paper›PMID 41366576›Full record

ArticleAnnals of biomedical engineering2026

Experimental Validation of Large Eddy Simulation as a Benchmark for Reynolds-Averaged Navier-Stokes Flow Modeling in a Magnetically Levitated Blood Pump.

Jonas Abeken, Utku Gülan, Kai von Petersdorff-Campen, Vasileios Charitatos, Marianne Schmid Daners, Mirko Meboldt, Markus Holzner, Diane de Zélicourt, Vartan Kurtcuoglu

Abstract readValidation Study
In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas AbekenInterface Group, Department of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-2025-0595
Utku GülanHi-D Imaging, Winterthur, Switzerland.ORCID http://orcid.org/0000-0002-8639-6936
Kai von Petersdorff-CampenProduct Development Group Zurich, Institute of Materials, Design and Fabrication, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-4827-6597
Vasileios CharitatosInterface Group, Department of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1312-6126
Marianne Schmid DanersInstitute for Dynamic Systems and Control, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6411-8871
Mirko MeboldtProduct Development Group Zurich, Institute of Materials, Design and Fabrication, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5828-5406
Markus HolznerEnvironmental Fluid Mechanics Group, Institute of Hydraulic Engineering and River Research, University of Natural Resources and Life Sciences BOKU, Vienna, Austria.ORCID http://orcid.org/0000-0003-2702-8612
Diane de ZélicourtInterface Group, Department of Physiology, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5300-1355
Vartan KurtcuogluInterface Group, Department of Physiology, University of Zurich, Zurich, Switzerland. vartan.kurtcuoglu@uzh.ch.ORCID http://orcid.org/0000-0003-2665-0995

Funding

Hartmann Müller-Stiftung für Medizinische Forschung 2508
6 · The paper itself

Abstract

purposeThis study investigates the potential of large eddy simulation (LES) as a benchmark for validating Reynolds-averaged Navier-Stokes (RANS) models in the CentriMag centrifugal blood pump. We compare velocity field predictions from LES and RANS against particle image velocimetry (PIV) and quantify previously unreported non-rotatory components in the motion of the magnetically levitated impeller, assessing their impact on flow dynamics.

methodsWe performed PIV on an optically accessible pump replica and compared phase-averaged velocity fields with computational fluid dynamics (CFD) predictions from LES and three unsteady RANS models. In addition, using custom optical trackers embedded in the PIV setup, we quantified the three-dimensional impeller motion and replicated its main non-rotatory components in the simulations.

resultsThe impeller exhibited complex but small deviations from ideal rotation. When incorporated into the CFD model, these had negligible impact on the flow field. LES predictions agreed well with PIV data, with root-mean-square velocity errors of approximately 3%, while the RANS models showed larger local deviations, particularly in the outlet region.

conclusionLES demonstrated close agreement with PIV and proved to be a reliable reference for validating RANS models in this study. Although the analysis was limited to a single pump, LES warrants further consideration as a potential benchmark method that could reduce reliance on extensive experimental flow validation. Consistent with previous findings, the transition from the volute to the outlet emerged as a particularly sensitive region for RANS modeling and validation. The quantified non-rotatory impeller motion had negligible impact on the flow field, supporting the continued use of idealized rotor motion in CFD modeling of similar magnetically levitated devices.

Indexed as

Heart-Assist DevicesModels, CardiovascularComputer SimulationHumansHydrodynamicsComputational fluid dynamicsLESMagLevPIVRANSVelocimetryVentricular assist device

Identifiers

PMID41366576
PMCPMC12960318

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.