Evidence map›Paper›PMID 41366532›Full record

ArticleLeukemia2026

Key regulatory roles of PRDM1 in human NK-cell differentiation and activation.

Xuxiang Liu, Yunfei Shi, Jibin Zhang, Kunal Shetty, Krystie Chew, Can Küçük, Qiang Gong, Esra Esmeray, Haiqing Li, Ru Chen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Role of PRDM1 in natural killer cells.Molecular biology reports · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xuxiang Liu *Department of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Yunfei Shi *Department of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Jibin Zhang *Department of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.ORCID 0000-0003-3099-6665
Kunal ShettyDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Krystie ChewDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Can KüçükDepartment of Medical Biology, Faculty of Medicine, Dokuz Eylül University, İzmir, 35340, Türkiye.ORCID 0000-0001-5540-9012
Qiang GongDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.ORCID 0000-0001-8502-6813
Esra EsmerayBasic and Translational Research Program, İzmir Biomedicine and Genome Center, İzmir, 35340, Türkiye.
Haiqing LiIntegrated Genome Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.
Ru ChenDepartment of Medicine-Gastroenterology, Baylor College of Medicine, Houston, TX, USA.
Sheng PanInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Katarzyna DąbrowskaIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.ORCID 0000-0001-7833-0374
Roger E MooreIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.ORCID 0000-0002-8907-2144
Krystine Garcia-MansfieldIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.
Patrick PirrotteIntegrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA.
Jinhui WangIntegrated Genome Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-3499-4336
Yuping LiDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Gehong DongDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Logan LeeDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
Timothy W McKeithanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA.ORCID 0000-0003-2242-3074
Javeed IqbalDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-3668-0629
Wing C ChanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, 91010, USA. jochan@coh.org.ORCID 0000-0002-6243-6008

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

PRDM1, encoding a transcription factor (TF), regulates plasma cell and CD8

Indexed as

Cell DifferentiationKiller Cells, NaturalLymphocyte ActivationPositive Regulatory Domain I-Binding Factor 1Gene Expression ProfilingGene Expression RegulationHumansPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, human

Identifiers

PMID41366532
PMCPMC12789010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.