Evidence map›Paper›PMID 41366531›Full record

ArticleLeukemia2026

REL overexpression and sustained NF-κB signaling associated with 2p gain induce resistance to BTK inhibitors in Chronic Lymphocytic Leukemia.

Léa Dehgane, Eliane Mallet, Constance Brasseur, Daphné Krzisch, Wail Zeitouni, Casilda Hitier, Marianne Ayoub, Kenza Dubois, Claudia Pérez Carretero, Damien Roos-Weil and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Léa DehganeCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Eliane MalletCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Constance BrasseurCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Daphné KrzischCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Wail ZeitouniGenoSplice Technology, Paris Biotech Santé, Paris, France.
Casilda HitierCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Marianne AyoubCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Kenza DuboisCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.ORCID http://orcid.org/0009-0000-8288-5217
Claudia Pérez CarreteroTranslational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva and Swiss Cancer Center Leman, Geneva, Switzerland.
Damien Roos-WeilCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Sylvain ChoquetService d'Hématologie Clinique, Hôpital Pitié-Salpêtrière, Sorbonne Université AP-HP, Paris, France.ORCID http://orcid.org/0000-0002-7791-0470
Karim MaloumService d'Hématologie Biologique, Hôpital Pitié-Salpêtrière, Sorbonne Université AP-HP, Paris, France.ORCID http://orcid.org/0000-0001-8864-4801
Clotilde BravettiCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Marine ArmandCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.
Delphine GarnierCentre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France.ORCID http://orcid.org/0000-0002-5744-5612
Jesús-María Hernández-RivasUniversity of Salamanca, IBSAL, IBMCC, CSIC, Cancer Research Center, Salamanca, Spain.ORCID http://orcid.org/0000-0002-9661-9371
Santos A Susin *Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France. santos.susin@inserm.fr.ORCID http://orcid.org/0000-0002-3366-1628
Florence Nguyen-Khac *Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France. florence.nguyen-khac@aphp.fr.
Elise Chapiro *Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Inserm UMRS 1138, Drug Resistance in Hematological Malignancies Team, Paris, France. elise.chapiro@aphp.fr.ORCID http://orcid.org/0000-0003-3427-7596
French Innovative Leukemia Organization (FILO)

Funding

Association Laurette Fugain (Laurette Fugain) 2024/11Ligue Contre le Cancer RS25/75-76Ligue Contre le Cancer TADH27012
6 · The paper itself

Abstract

The gain of chromosome 2p (2p

Indexed as

Agammaglobulinaemia Tyrosine KinaseDrug Resistance, NeoplasmLeukemia, Lymphocytic, Chronic, B-CellNF-kappa BProtein Kinase InhibitorsAdenineGene Expression Regulation, LeukemicHumansPiperidinesSignal TransductionTumor Cells, CulturedAdenineAgammaglobulinaemia Tyrosine KinaseBTK protein, humanibrutinibNF-kappa BPiperidinesProtein Kinase Inhibitors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.