ArticleIntensive care medicine experimental2025
Kinetics of molecular patterns captured by mannose-binding lectin in septic shock correlate with clinical outcome: a monocentric prospective observational study.
Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03457038 (Use of Fc Mannose-Binding Lectin to Detect and Monitor the Presence of Pathogen-Associated Molecular Patterns During Septic Shock), which is not on this map. Not yet cited in PubMed.
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Use of Fc Mannose-Binding Lectin to Detect and Monitor the Presence of Pathogen-Associated Molecular Patterns During Septic Shock
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious serum biomarkers and scoring systems are currently employed to manage septic critically ill patients. However, a paucity of biomarker evidence facilitates sepsis identification or prognosis. Mannose-binding lectin (MBL) is the main circulating protein in innate immunity. It acts as a broad-spectrum recognition molecule that binds most pathogens, along with their breakdown products and cell debris. We report results of an original approach dosing molecular patterns captured by FcMBL, an engineered version of MBL, in patients with septic shock. This study aimed at evaluating molecular patterns kinetics to assess their potential contribution to the clinical management of critically ill patients suffering from septic shock.
resultsThis monocentric, prospective, observational study was conducted on adults admitted to the intensive care unit (ICU) for septic shock. Using magnetic microbeads coated with FcMBL, we quantified molecular patterns captured in blood and analyzed their kinetics for 5 days. Pathogen-associated molecular patterns (PAMP) levels were sampled at 6-h intervals over the first 24 h of ICU admission, then at 12 h intervals on Day 2, and then daily through Day 5. To align the data from the real time of admission to the ICU, the "Serial Measurements" module in MedCalc
conclusionsMolecular pattern levels captured by FcMBL during septic shock exhibited large inter-patient variability, suggesting values depend on numerous parameters. The signal's kinetics demonstrated predictive value and may contribute to clinical management.
trial registrationclinicaltrials, NCT03457038, Registered 15 October 2017, https://clinicaltrials.gov/study/NCT03457038.
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