ArticleJournal of pharmaceutical health care and sciences2025
Factors associated with the effectiveness of opioids for dyspnea in hospitalized patients with heart failure: a retrospective, multicenter, observational study.
Article in Journal of pharmaceutical health care and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Opioid Use for Dyspnoea in Advanced Heart Failure.Current heart failure reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe decision to administer opioids for dyspnea caused by heart failure should be made on an individual basis. However, factors associated with the effectiveness of opioids remain unclear, and information that could guide this decision is lacking. This study aimed to explore factors associated with the effectiveness of opioids to relieve dyspnea caused by heart failure.
methodsThis retrospective, multicenter, observational study included patients 18 years of age or older at the time of admission who received opioid administration (morphine, oxycodone, or hydromorphone) for dyspnea relief but did not receive invasive ventilatory support during hospitalization. Data were collected from the medical records.
resultsA total of 129 cases (30 ineffective cases, 80 effective cases, and 19 cases with missing dyspnea assessment data) were collected. The multivariable logistic regression analysis results indicated that the odds ratios of the New York Heart Association classification, number of diuretics used, and oxygen flow rate associated with the presence or absence of dyspnea improvement attributable to opioid administration were 0.496 (95% confidence interval, 0.254–0.967), 1.506 (95% confidence interval, 1.131–2.007), and 0.974 (95% confidence interval, 0.923–1.027), respectively. Trends in odds ratios for both the number of diuretics used and New York Heart Association classification were preserved in the multivariable logistic regression model that included factors that potentially influence dyspnea (p < 0.05).
conclusionThe effectiveness of opioids for relieving dyspnea caused by heart failure in hospitalized patients was positively associated with the number of diuretics used and negatively associated with the New York Heart Association classification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.