Evidence map›Paper›PMID 41366456›Full record

ArticleCell & bioscience2025

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.

Alessandra Bigi, Andrea Carlotta Conti, Liliana Napolitano, Giuliana Fusco, Alfonso De Simone, Fabrizio Chiti, Roberta Cascella, Cristina Cecchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandra BigiDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy.ORCID http://orcid.org/0000-0002-1067-6288
Andrea Carlotta ContiDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy.
Liliana NapolitanoDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy.
Giuliana FuscoDepartment of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.ORCID http://orcid.org/0000-0002-3644-9809
Alfonso De SimoneDepartment of Pharmacy, University of Naples, 80131, Naples, Italy.ORCID http://orcid.org/0000-0001-8789-9546
Fabrizio ChitiDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy.ORCID http://orcid.org/0000-0002-1330-1289
Roberta CascellaDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy. roberta.cascella@unifi.it.ORCID http://orcid.org/0000-0001-9856-6843
Cristina CecchiDepartment of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, 50134, Florence, Italy. cristina.cecchi@unifi.it.ORCID http://orcid.org/0000-0001-8387-7737

Funding

Italian MUR - National Recovery and Resilience Plan (NRRP) Investment PE8 - Project Age-It: "Ageing Well in an Ageing Society" (D.R. 1557 11.10.2022)Italian MUR - National Recovery and Resilience Plan (NRRP) project MNESYS (PE0000006) - A Multiscale integrated approach to the study of the nervous system in health and disease (D.R. 1553 11.10.2022)University of Florence Fondi di AteneoUniversity of Florence RICTD2024-2025 project VANGUARD)
6 · The paper itself

Abstract

backgroundThe aggregation of α-Synuclein (αS) into amyloid fibrils and their deposition in intraneuronal Lewy bodies are hallmark features of Parkinson's disease (PD) and other synucleinopathies. Among the molecular players implicated in αS toxicity, the cellular prion protein (PrP

resultsUsing confocal microscopy, colocalization analysis and both siRNA-induced PrP

conclusionsCollectively, our findings indicate that while PrP

Indexed as

AmyloidFibrilsLewy bodiesNeurodegenerationParkinson's DiseaseProtein aggregationProtein misfoldingSynucleinopathiesToxic oligomers

Identifiers

PMID41366456
PMCPMC12687500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.