Evidence map›Paper›PMID 41366416›Full record

ArticleBMC biology2025

Unveiling a novel broad-host-range cyanomyovirus cross-infecting Prochlorococcus and Synechococcus.

Shuang Wei, Lanlan Cai, Hongrui Zheng, Shuzhen Wei, Bu Xu, Rui Zhang, Yongle Xu, Jiangtao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuang Wei *State Key Laboratory of Marine Geology, Tongji University, Shanghai, 200092, China.
Lanlan Cai *Earth, Ocean and Atmospheric Sciences Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou, 511453, China.
Hongrui ZhengInstitute of Marine Science and Technology, Shandong University, Qingdao, 266237, China.
Shuzhen WeiState Key Laboratory of Marine Geology, Tongji University, Shanghai, 200092, China.
Bu XuArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Rui ZhangArchaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518055, China.
Yongle XuInstitute of Marine Science and Technology, Shandong University, Qingdao, 266237, China. xuyongle@sdu.edu.cn.
Jiangtao LiState Key Laboratory of Marine Geology, Tongji University, Shanghai, 200092, China. jtli@tongji.edu.cn.

Funding

Guangdong Major Project of Basic and Applied Basic Research 2023B0303000017Innovation Team Project of Universities in Guangdong Province No. 2023KCXTD028National Natural Science Foundation of China 42576085National Natural Science Foundation of China No. 42072333
6 · The paper itself

Abstract

backgroundCyanophages, viruses that infect cyanobacteria, are diverse and ubiquitous in the marine environment and play important roles in regulating the host community's structure, dynamics, and metabolism. Isolation is an efficient method to explore the genetic diversity of cyanophages and their interactions with hosts. However, our understanding of these interactions is still limited, and further in-depth research is needed to address this gap.

resultsIn this study, we report a novel marine T4-like cyanophage, S-SCSM2R, that is able to cross-infect eight picocyanobacterial phylogenetic clades, including three Prochlorococcus clades of both high-light and low-light ecotypes and eight Synechococcus subclades across all five Synechococcus clades of 5.1, 5.2, 5.3, Subalpine II and Bornholm Sea. S-SCSM2R contains novel auxiliary metabolic genes involved in photosynthesis, alleviation of oxidative stress, cell wall synthesis and modification, and antibiotic synthesis. Alongside the receptor-binding protein gene, a set of counter-defense genes related to DNA methylation and NAD

conclusionsS-SCSM2R has an extremely broad host range and novel genetic features related to phage-host interactions. The discovery and characterization of S-SCSM2R broaden our knowledge of cyanophage cross-infectivity and reveal new ways in which cyanophages manipulate host metabolism in marine ecosystems.

Indexed as

BacteriophagesHost SpecificityProchlorococcusSynechococcusPhylogenyAuxiliary metabolic genesCross-infectivityCyanophageProchlorococcusSynechococcus

Identifiers

PMID41366416
PMCPMC12801897

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.