ArticleBMC women's health2025
Bidirectional causal relationship between inflammatory cytokines and endometriosis at different sites.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Causal interplay between lactose intolerance and gut microbiota: a combined bidirectional Mendelian randomization andFrontiers in nutrition · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis study aims to explore the genetic connection between inflammatory cytokines (IC) and endometriosis (EMs) to provide insights for the treatment of EMs.
methodsData from two genome-wide association studies (GWAS) on IC and EMs were analyzed for single nucleotide polymorphisms (SNPs). Both forward and reverse Mendelian randomization (MR) analyses were conducted using inverse variance weighting. In the forward MR analysis, IC-related SNPs were used as instrumental variables with EMs as the outcome. Conversely, in the reverse MR analysis, SNPs associated with EMs were used as instrumental variables with IC as the outcome. Analyses were conducted using the TwoSampleMR package in R.
resultsThe forward MR analysis revealed no significant genetic correlation between 51 ICs and EMs (P > 0.05). The reverse MR analysis, however, revealed a significant genetic correlation between EMs and one type of IC (P < 0.05), with no significant correlations for the others (P > 0.05). Notably, specific inflammatory factors varied among different EMs sites (P < 0.05).
conclusionAlthough ICs do not have a genetic influence on EMs, variations in inflammatory factors are observed in EMs patients, especially across different EMs sites. These findings suggest unique inflammatory responses at specific EMs sites.
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Registered trials
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