Evidence map›Paper›PMID 41366390›Full record

ArticleLipids in health and disease2025

Sex-related disparities in hyperlipidaemia and cardiovascular risk in Sri Lanka: a cross-sectional study.

Chamila Mettananda, Kavindya Fernando, Maheeka Solangaarachchige, Ravini Premaratna, Randula Mallawa, Upeksha Fernando, Arundika Senaratne, Udara Perera, Champika Wickramasinghe

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Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Chamila MettanandaDepartment of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. chamila@kln.ac.lk.
Kavindya FernandoDepartment of Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Maheeka SolangaarachchigeExamination Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Ravini PremaratnaDepartment of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Randula MallawaDepartment of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Upeksha FernandoDepartment of Pharmacology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Arundika SenaratneNCD Directorate, Ministry of Health, Colombo, Sri Lanka.
Udara PereraNCD Directorate, Ministry of Health, Colombo, Sri Lanka.
Champika WickramasingheNCD Directorate, Ministry of Health, Colombo, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNearly 80% of the world’s noncommunicable disease (NCD) burden comes from developing countries, where sex-related disparities in healthcare utilisation are common. However, studies on sex-related disparities in lipids and cardiovascular risk among South Asians are limited. This study aimed to investigate sex-related differences in the prevalence, management and outcome of lipids and related cardiovascular diseases (CVDs) among Sri Lankans to inform necessary improvements in preventing, diagnosing, and managing CVDs in females in Sri Lanka, a resource-limited South Asian setting.

methodsSecondary data from the World Health Organisation’s STEPS survey-2021, a community-based cross-sectional study conducted across Sri Lanka from April to December 2021, were analysed. Hyperlipidaemia was defined as having a total cholesterol (TC) level ≥ 200 mg/dL or being on treatment for hyperlipidaemia. TC goal was defined as a TC level < 200 mg/dL. Rates of hyperlipidaemia prevalence, treatment uptake and TC target achievement were compared between males and females. Sex-related disparities in the associations of hyperlipidaemia and CVDs were assessed separately.

resultsThe study sample consisted of 4,634 adults (62.8% female) with a mean age of 46 ± 13.7 years. The prevalence of hyperlipidaemia was higher in females (46.3%) than in males (36.4%, P < 0.001). Treatment uptake was not significantly different between females (25.2%) and males (23.6%, P = 0.467). Of those on treatment for hyperlipidaemia, the TC goal achievement was low in females (68.1%) compared to males (82.4%, P < 0.001). Females (4.9%) had a lower prevalence of established CVDs compared to males (10.9%, P < 0.001), but females with hyperlipidaemia had higher odds (OR 1.24, P = 0.038) of CVDs.

conclusionsSri Lankan females had a higher prevalence and poorer control of hyperlipidaemia compared to males, despite no significant difference in treatment uptake. However, the presence of CVDs was higher among males and was independently associated with sex and hyperlipidaemia.

Indexed as

Cardiovascular DiseasesHyperlipidemiasAdultAgedCholesterolCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedPrevalenceRisk FactorsSex FactorsSri LankaCholesterolCardiovascular diseasesCholesterolHealth resourcesHyperlipidaemiaSex factorsSri lanka

Identifiers

PMID41366390
PMCPMC12802009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.