SynthesisBMC oral health2025
Is injectable platelet rich fibrin beneficial in managing intracapsular temporomandibular disorders? A systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Standalone Intra-Articular Injections for Temporomandibular Joint Disorders: Overview of Meta-Analytic Evidence.Journal of clinical medicine · 2026Review
- Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo highlight the current knowledge of the effectiveness of injectable platelet rich fibrin (i-PRF) in the management of temporomandibular joint internal derangement (TMJ-ID) and temporomandibular joint osteoarthritis (TMJ-OA). METHODOLOGY: A "Population, Intervention, Comparison, Outcome" (PICO) strategy was implemented by performing a systematic search through Cochrane databases, PubMed/MEDLINE, and Google Scholar from their commencement to November 2024. Randomized clinical trials (RCTs) addressing the management of TMJ-ID and TMJ-OA with i-PRF were included. Two reviewers independently evaluated the suitability of the RCTs, followed by data extraction.
resultsThe electronic search revealed 274 articles, but only 6 studies were deemed suitable for selection, with a total of 270 subjects; 75% were females, and 25% were males. Meta-analysis revealed a significant reduction in pain levels with i-PRF compared to controls (pooled SMD = - 2.16; 95% CI = - 3.43 to - 0.89; P < 0.001). Significant improvement was also observed in maximum mouth opening (SMD = 2.46; 95% CI = 0.56 to 4.36; P = 0.02). i-PRF significantly enhanced lateral mandibular movements compared with controls (SMD = 1.35; 95% CI = 0.03 to 2.67; P = 0.048), whereas no significant difference was found for protrusive movements (SMD = 1.76; 95% CI = - 0.97 to 4.48; P = 0.11). Improvements in joint sounds and disc position were qualitatively reported in smaller subsets of studies. Substantial heterogeneity (I² = 83-93%) was observed across outcomes, reflecting variability in study design and treatment protocols.
conclusionCurrent evidence suggests that i-PRF provides improvements in TMJ pain, joint sounds, and mandibular movements for up to 12 months. However, more RCTs are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.