Colloidal stability and controlled release of Au@SiO₂ and Ag@SiO₂ core-shell nanostructures from biopolymer-based hydrogels.

Agata Kowalska, Elżbieta Adamska, Anna Wcisło, Kinga Deja, Adrianna Kalinowska, Beata Grobelna

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Agata KowalskaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland.ORCID http://orcid.org/0000-0001-6620-3976

Elżbieta AdamskaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland. elzbieta.adamska@ug.edu.pl.ORCID http://orcid.org/0000-0003-1115-1894

Anna WcisłoFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland.ORCID http://orcid.org/0000-0002-8943-423X

Kinga DejaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland.

Adrianna KalinowskaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland.

Beata GrobelnaFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk, 80-308, Poland. beata.grobelna@ug.edu.pl.ORCID http://orcid.org/0000-0003-2122-2238

Funding

Univeristy of Gdańsk 533-BG20-GS13-25Univeristy of Gdańsk 539-T050-B198-25

6 · The paper itself

Abstract

Nanotechnology offers innovative strategies for developing multifunctional cosmetic ingredients. Here, we synthesize Au@SiO₂ and Ag@SiO₂ core-shell nanostructures with high shape and size uniformity, colloidal stability, and hydrophilicity. The silica shell stabilizes the metal core and enables surface functionalization, enhancing applicability in biopolymer-based formulations. We characterize the nanomaterials using UV-Vis spectroscopy, TEM, DLS, zeta potential, and contact angle measurements, confirming well-defined core-shell morphology and favorable surface properties. Both nanostructures display comparable antioxidant activity, while Ag@SiO₂ exhibits superior catalytic efficiency. To evaluate delivery performance, we incorporate the nanoparticles into sodium hyaluronate (HA) and hydroxyethylcellulose (HEC) hydrogels. The hybrid gels maintain homogenous morphology and enable tunable nanoparticle release profiles: HA gels promote rapid release and significantly improve skin hydration, whereas HEC gels provide sustained release suitable for prolonged action. These results demonstrate that Au@SiO₂ and Ag@SiO₂ nanostructures act as versatile, stable, and bioactive components for cosmetic and biomedical formulations. The study highlights the potential of core-shell nanomaterials at soft matter interfaces, combining antioxidant and antimicrobial functionality with controlled delivery and enhanced skin barrier performance.

Indexed as

Ag@SiO2Au@SiO2Biopolymer hydrogelsColloidal stabilityControlled releaseCore–shell nanostructures

Identifiers

PMID41366278

DOI10.1038/s41598-025-30547-8

PMCPMC12783122

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.