ArticleScientific reports2025
Prognostic nutritional indices predict 60 day mortality in ICU patients with sepsis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of the prognostic nutritional index in sepsis, pneumonia, and tuberculosis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury-A Retrospective Cohort Study Based on the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Association of obesity and nutritional status on early sepsis-associated acute kidney injury in older patients with sepsis.BMC nephrology · 2026Article
- Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Prognostic nutritional index at discharge as a practical bedside tool for long-term all-cause mortality risk in pneumonia-induced sepsis survivors.Frontiers in nutrition · 2026Article
- Comparative evaluation of five nutrition-inflammation indices for predicting 28-day ICU mortality in critically ill patients with bone infections: a dual-cohort study with external validation and interpretable machine learning.Frontiers in nutrition · 2026Article
- A risk prediction model based on immune-inflammatory-nutritional indicators for predicting 28-day mortality in sepsis patients with acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
- Nutritional Risk and 30-Day In-Hospital Mortality in Adults With Sepsis and Septic Shock: A Retrospective Cohort Study.Journal of nursing management · 2026Article
- An explainable prognostic prediction panel for sepsis based on serum amino acid profiles.Frontiers in immunology · 2026Article
- Association between MDROs colonization and subsequent infections in ICU patients: a retrospective cohort study.Frontiers in public health · 2026Article
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Authors and funding
5 authors.
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Abstract
Sepsis is frequently accompanied by severe metabolic disturbances and malnutrition, with nutritional status being an important modifiable factor affecting patient outcomes. The Prognostic Nutritional Index (PNI) and the Geriatric Nutritional Risk Index (GNRI) are multidimensional tools for assessing nutritional status. However, the association between PNI/GNRI and 60-day mortality in patients with sepsis remain inadequately elucidated. This study aimed to evaluate the value of PNI and GNRI for predicting the mortality risk in sepsis based on analysis of data from the MIMIC-IV database. A total of 1649 patients with sepsis were enrolled and stratified into tertiles of PNI and GNRI. We performed Kaplan-Meier survival analysis, multivariate Cox regression analysis, restricted cubic spline (RCS) analysis, complemented by subgroup analyses stratified by age, comorbidities, and treatments. Patients in the PNI- and GNRI-Q3 groups (high-score groups) demonstrated a 53% reduction in 60-day mortality risk relative to those in the PNI- and GNRI-Q1 groups (low-score groups) [hazard ratio (HR) = 0.47, 95% confidence interval (CI): 0.30-0.73]. RCS analysis revealed a nonlinear inverse correlation between PNI and mortality risk, with elevated mortality risk (HR > 1) observed at low scores of PNI (< 20). Subgroup analyses indicated that PNI exhibited more pronounced protective effects in patients aged ≤ 65 years (HR = 0.33) and those treated with β-lactam antibiotics (HR = 0.38). In contrast, GNRI showed better predictive value in elderly patients (> 65 years, HR = 0.61) and those with diabetes (HR = 0.37). Both PNI and GNRI are independent predictors of 60-day mortality in patients with sepsis. By integrating nutritional and immunological parameters, they provide valuable prognostic value beyond conventional measures. Incorporating PNI and GNRI into risk evaluation frameworks may help identify patients who may benefit from early nutritional interventions.
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